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MEETING: “Cancer Epigenetics and Metabolism: Connecting the Dots”

February 2 and 3, 2015, Biocant Park, Cantanhede, Portugal
DAY 1, February 2
8:30 – 9:15 Registration
9:15 – 9:30 Opening of the meeting
9:30 – 10:30 Opening Plenary Lecture, Paolo Sassone-Corsi, University of California – Irvine, USA “Metabolism and epigenetics: the Clock link”
10:30 – 11:15 Valdemar Maximo, IPATIMUP, University of Porto, Portugal “Mitochondrial regulation of epigenetics and its role in human diseases”
11:15 – 11:45    Coffee break, meet the sponsors
11:45 – 12:30 Gabriella Ficz, Barts Cancer Institute, University of London, UK “Role of epimutations in cellular transformation”
12:30 – 13:00 Michael Rhodes, Nanostring Technologies, USA, “Translational Research: from Research to Diagnostics. The NanoString Digital Technology”
13:00 – 13:20 Selected short oral talk S1: Ana S. Rodrigues, CNC, Portugal, “Pyruvate dehydrogenase and pluripotency: can we affect pluripotency metabolically?”
13:20 – 15:00    Lunch and poster session
15:00 – 16.00 Plenary lecture, Carmen Jerónimo, Portuguese Oncology Institute-Porto (IPO-Porto) & ICBAS-UP, Portugal “Epigenetic deregulation in urological tumors: from biology to clinics”
16:00 – 16:45 Florian Pauler, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria “Imprinted long non coding (lnc) RNAs as a paradigm for functional lncRNAs in development and cancer
16:45 – 17:15    Coffee break, meet the sponsors
17:15 – 17:35 Selected short oral talk S2: Ricardo P. Neves, CNC, Portugal and MRC Molecular Haematology Unit, University of Oxford, UK “Connecting the dots between cellular mitochondrial content and global variability in gene expression and alternative splicing”
17:35 – 17:55 Selected short oral talk S3: Teresa L. Serafim, CNC, Portugal, “Mitochondrial characterization of human breast cancer cell lines for in vitro cancer research”
17:55 – 18:15 Selected short oral talk S4: Maria I. Almeida, INEB and Instituto de Investigação e Inovação em Saúde, Portugal “Extracellular vesicles derived from mesenchymal stem/stromal cells contain microRNAs involved in osteoblast differentiation”
20:00                   Meeting dinner
DAY 2, February 3
9:30 – 10:30

Plenary Lecture, Frederick Domann, University of Iowa, USA “Mitochondrial redox metabolism and its influence on the epigenetic control of gene expression”

10:30 – 11:15

John Jones, CNC, University of Coimbra, Portugal “Metabolic flux profiling of cancer cells using deuterated water and 13C-tracers

11:15 – 11:45    Coffee break, meet the sponsors
11:45 – 12:30

Maarten Van Lohuizen, Netherlands Cancer Institute, Amsterdam, The Netherlands “Unexpected results of prolonged Ezh2 inhibition in an in vivo model for Glioblastoma

12:30 – 12:50 Selected short oral talk S5: Fátima Martel, Faculty of Medicine, University of Porto, Portugal “The anticarcinogenic effect of the dietary compound kaempferol in a human breast cancer cell line is dependent on inhibition of glucose cellular uptake”
12:50 – 15:00    Lunch and poster session
15:00 – 15.45 João T. Barata, Institute of Molecular Medicine, Lisbon, Portugal “Signaling, Oncogenes and T-cell Leukemia”
15:45 – 16:45 Roundtable “Cancer Epigenetics and Metabolism: Connecting the Dots?”, moderated by: Frederick Domann, University of Iowa, USA
16:45 – 17:15    Coffee break, meet the sponsors
17:15 – 17:35 Selected short oral talk S6: Luciana Ferreira, CNC, Portugal, “Persistent effects in mitochondrial genes transcription after incubation of H9c2 cells with the anticancer drug Doxorubicin: an epigenetic origin?”
17:35 – 17:55

Selected short oral talk S7: Sofia Gomes, Faculty of Pharmacy, University of Lisbon, Portugal “miR-143 and miR-145 overexpression in HCT116 colon cancer cells enhances cetuximab-mediated antibody-dependent cellular cytotoxicity leading to increased apoptosis”

17:55 – 18:15 Selected short oral talk S8: Marcelo Correia, CNC, Portugal, “Histone deacetylase proteins: a possible glycolytic metabolic shifter in embryonic stem cells”
18:15 – 18:30    Closing session

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