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An intensive hands-on training program oriented towards discovering and understanding new organization principles in organism and molecular Biology.

Systems biology is beginning to unveil organization principles that apply across organisms, cell types and modules, raising the hope that Biology too will become a predictive science. Such principles emerge from the interplay between three factors. Namely, the physical-chemical limits that constrain what organisms can accomplish given the available resources; the performance requirements that organisms must fulfill in their environment in order to effectively spread their genes onto the next generation; and the evolutionary dynamics that determine if and how feasible designs become prevalent in populations. This summer school will provide training on the theoretical foundations and computational tools that are required to achieve a deeper appreciation of that interplay.

Focus of 2015 edition:
Organizing Principles of Redox Biology
Reactive oxygen and nitrogen species (RONS) such as hydrogen peroxide, and nitric oxide are now known to play critical roles in signal transduction and in coordinating key cellular processes. However, these species can also covalently damage macromolecules and originate other even more reactive species. General principles how organisms exploit the properties of RONS for regulation while avoiding their deleterious effects are just beginning to emerge. PrOSysBio2015 will focus on reviewing recent advances, introducing key concepts and computational tools and fostering a multidisciplinary exchange of ideas towards discovering and understanding new general organization principles in this area.

Topics covered:
     - Kinetic and thermodynamic principles of thiol redox regulation
     - Kinetic modeling and dynamic analysis of biomolecular networks in redox signaling and antioxidant protection
     - Design principles of biomolecular networks: methods and examples
     - Evolutionary adaptation of protein composition and structure to oxidative stress

Target audience
     • Graduate students and postdocs seeking to become familiar with the principles of redox biology and/or with computational
       methods available for relating design to function.
     • Researchers at any level who are interested in principles of biological organization and seek to acquire these skills.

We welcome both applicants with exact sciences or engineering backgrounds and applicants with a biology background. However, a good quantitative background is desirable in all cases.

Course structure
The course takes a student-oriented approach and is composed of lectures and computational research projects. Project themes will be presented on day 1. The first part of the course will emphasize lectures covering the main topics. During that time students will also choose their research projects and teams, and devise a research plan. Teams will include students with complementary backgrounds and will be coached by tutors. The second part of the course will be devoted to executing the research projects. Results will be presented in the last day at a mini-symposium.


                                                                                                                    


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