Ongoing
Projects (Reference and theme) |
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-POCI-01-0145-FEDER-016795 -
Schizophrenia |
-POCI-01-0145-FEDER-016428
- Parkinson's Disease, Alzheimer's
Disease, Schizophrenia and Autism |
-ROTEIRO/0028/2013 - National Mass
Spectrometry Network |
-PTDC/NEU-NMC/0205/2012 - Parkinson's
Disease |
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Past projects included the following: |
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-PTDC/CVT-EPI/3460/2012 -
Proteomics of tick |
-EXCL-DTP-PIC-0069-2012 - Diabetes |
-PTDC/SAU-NEU/103728/2008
- Schizophrenia |
-PTDC/SAU-OBD/104017/2008
- Cancer |
-PIC/IC/83206/2007 -
Alzheimer's disease |
-QREN, reference 21576
- Wine |
-QREN, reference 30272
- Wine |
-PTDC/EBB-BIO/098111/2008 -
Glucose metabolism |
-PTDC/SAU-NEU/099440/2008 -
Synaptic plasticity |
-Brain-Derived Neurotrophic Factor
induced changes in the proteome of cultured hippocampal neurons.
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-Identification of biomarkers for Multiple
Sclerosis in the cerebrospinal fluid and serum
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-Proteomic characterization of AMPA receptor-interacting
proteins
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-Identification of proteolytic cleavage
sites in VGLUT2
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-Identification of Post-Translational
Modifications (PTM's) in different projects, including neurodegenerative
disorders
-Identification of protein isoforms and
protein contaminants occuring in recombinant protein synthesis
-Identification and quantitation of
possible biomarkers in neurodegenerative disorders
-Identification of extracellular
neuronal signalling proteins
-Identification and quantitation of
diabetes related protein modifications
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Publications:
(complete list in google scholar
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to be updated: |
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-Matrisome Profiling During
Intervertebral Disc Development And
Ageing. Caldeira, J., C. Santa, H.
Osório, M. Molinos, B. Manadas, R.
Gonçalves and M. Barbosa (2017).
Scientific Reports 7(1): 11629. doi:
10.1038/s41598-017-11960-0, IF: 4.259.
full text |
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-Nuno Rosa, Jéssica Marques, Eduardo
Esteves, Mónica Fernandes, Vera M
Mendes, Ângela Afonso, Sérgio Dias,
Joaquim Polido Pereira, Bruno Manadas,
Maria José Correia, Marlene Barros;
“Protein Quality Assessment on Saliva
Samples for Biobanking Purposes”,
Biopreservation and biobanking, 2016,
doi:10.1089/bio.2015.0054, IF 1.34, Q3 ,
Link |
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-Gap junctional protein Cx43 is involved
in the communication between
extracellular vesicles and mammalian
cells, Ana R Soares, Tania Martins-Marques, Teresa Ribeiro-Rodrigues, Joao Vasco Ferreira, Steve Catarino, Maria João Pinho, Monica Zuzarte, Sandra I Anjo, Bruno Manadas, Joost Sluijter, Paulo Pereira, and Henrique Girão et al,
Nature Scientific Reports, Accepted
2015, IF: 5.578
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- Does Hypoxia/Normoxia Culturing Conditions Change the Neuroregulatory Profile of Wharton Jelly Mesenchymal Stem Cells Secretome? Fábio G Teixeira FGT, Krishna M Panchalingam KMP, Sandra I Anjo SA, Bruno Manadas BM, Ricardo Pereira RP, Nuno Sousa NS, António J Salgado AJS and Leo A Behie, Stem Cell Research & Therapy, 2015, Accepted, IF: 3.36
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- Bioaccessibility and changes on cylindrospermopsin concentration in edible mussels with storage and processing time, Marisa Freitas, Joana Azevedo, António Paulo Carvalho, Vera M. Mendes, Bruno Manadas, Alexandre Campos, Vitor Vasconcelos, Food Control, Q1, IF: 2.819 Accepted, 2015,
Link |
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- Does caffeine
consumption modify CSF amyloid beta levels in patients with
Alzheimer’s disease? Maria Travassos, Isabel Santana, Inês Baldeiras, Magda Tsolakid, Olymbia Gkatzimad, Sermin Gence, Görsev G. Yenere, Anja Simonsenf, Steen G. Hasselbalchf, Elisabeth Kapakig, Mara Bourboulig, Rodrigo Cunha, Paula Agostinho, Kaj Blennowh, Henrik Zetterbergh, Vera M. Mendes, Bruno Manadas, Alexandre de Mendonça, Journal of Alzheimer’s disease , Q2, IF 4.15, Accepted 2015 |
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- Analysis of Citalopram
in Plasma and Hair by a Validated LC-MS/MS Method, Pinto J, Mendes VM, Coelho M, Baltazar G, Pereira J LGC, Dunn MJ, Cotter DR and Manadas
B, Journal of Chromatography & Separation Techniques, Q3, IF 1.74, Accepted, 2015 |
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- Reduced α-MSH underlies hypothalamic endoplasmic reticulum stress-induced hepatic gluconeogenesis,
Marc Schneeberger, Alicia G. Gomez-Valades, Jordi Altirriba, David Sebastian, Sara Ramirez, Ainhoa Garcia, Yaiza Esteban, Anne Drougard, Albert Ferres-Coy, Analia Bortolozzi, Pablo M. Garcia-Roves, John G. Jones, Bruno Manadas, Antonio Zorzano, Ramon Gomis, Marc Claret , Cell Reports, Q1, IF:7.207, Accepted, 2015,
Link |
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- Effect of Global ATGL Knockout on Murine
Fasting Glucose Kinetics, Margarida Coelho, Patricia Nunes, Vera M. Mendes, Bruno Manadas, Arend Heerschap,
and John G. Jones, Journal of Diabetes Research, IF 3.536, Q2, 2015,
Link |
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- Short GeLC-SWATH: a
fast and reliable quantitative approach for proteomic screenings, Anjo, S. I.; Santa, C.; Manadas,
B., Proteomics (2014), DOI: 10.1002/pmic.201400221, ; IF:3.97, Q1,
Link |
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Comparative
Proteomic Analysis of Auxin-Induced
Embryogenic and Nonembryogenic Tissues
of the Solanaceous Tree Cyphomandra
betacea (Tamarillo), Correia, Sandra;
Vinhas, Raquel; Manadas, Bruno; et al.,
Journal of Proteome Research Volume: 11
Issue: 3 Pages: 1666-1675; 2012;
IF:5.11, Q1;
Link |
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- Partitioning
the Proteome: Phase Separation for
Targeted Analysis of Membrane Proteins
in Human Post-Mortem Brain, Jane A.; Manadas, Bruno; Scaife, Caitriona; et
al., Plos One Volume: 7 Issue: 6, 2012;
IF: 4.09, Q1;
Link,
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- Toward a
standardized saliva proteome analysis
methodology, Vitorino, Rui; Guedes,
Sofia; Manadas, Bruno; et al., Journal
of proteomics Volume: 75 Issue: 17 Pages:
5140-65; 2012; IF 4.88; Q1;
Link |
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- Analysis of
glucose metabolism in farmed European
sea bass (Dicentrarchus labrax L.) using
deuterated water, Viegas, Ivan; Mendes,
Vera M.; Leston, Sara; Manadas, Bruno,
et al. Comparative Biochemistry and
Physiology a-Molecular & Integrative
Physiology Volume: 160 Issue: 3 Pages:
341-347; 2011; IF 2.2; Q1;
Link |
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- Pollen
proteases compromise the airway
epithelial barrier through degradation
of transmembrane adhesion proteins and
lung bioactive peptides, Vinhas, R.;
Cortes, L.; Cardoso, I.; Mendes, Vera,
Manadas, Bruno,et al., Allergy Volume:
66 Issue: 8 Pages: 1088-1098; 2011; IF:
6.27; Q1,
Link |
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Peptide fractionation in proteomics
approaches, Manadas B, Mendes VM,
English JA, Dunn MJ, Expert Reviews of
Proteomics, 2010, v7 p655; IF:4.4,
Link, |
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- Proteomic analysis of an interactome for long-form AMPAreceptor
subunits,
Santos S, Manadas B, Duarte CB, Carvalho
AL, J Proteome Res. 2010 Apr 5;
9(4):1670-82;
IF: 5.68,
Link |
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- Comparative analysis of OFFGel, SCX
with pH gradient, and Reverse Phase at
high pH for first dimensional separation
of peptides from a membrane enriched
protein fraction; Manadas B, English JA, Wynne KJ, Cotter
DR, Dunn MJ,
Proteomics, 2009 Nov; 9(22):5194-8;
IF:4.59,
Link |
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- BDNF-induced changes in the expression
of the translation machinery in hippocampal neurons: protein levels and
dendritic mRNA; Manadas B,
Santos AR, Szabadfi K, Gomes JR, Garbis
SD, Fountoulakis M, Duarte CB., , J Proteome Res. 2009,
v8 p4536; IF: 5.68,
Link |
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- Genetic
Code Alteration Plays a Critical Role in
the Evolution of Candida Genes -
Quantitative Analysis of Single Amino
Acid Changes using a 4000 QTRAP® system;
Raquel M Silva, João A Paredes, Gabriela
R Moura, Bruno Manadas, Tatiana
Lima-Costa, Rita Rocha, Isabel Miranda,
Ana C Gomes, Marian J G Koerkamp, Michel
Perrot, Frank C P Holstege, Helian
Boucherie & Manuel A S Santos, ,
Technical Note, Applied Biosystems/MDS
Sciex, 2008; |
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- Critical roles for a genetic code
alteration in the evolution of the genus Candida; Silva RM, Paredes JA, Moura GR,
Manadas B, Lima-Costa T, Rocha R, Miranda I, Gomes AC, Koerkamp MJ, Perrot M, Holstege FC, Boucherie H, Santos MA.; EMBO J. 2007 Oct 31;26(21):4555-65.I.F. 8.66,
Link |
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- Sample sonication after
trichloroacetic acid precipitation increases protein recovery from cultured hippocampal
neurons, and improves resolution and
reproducibility in two-dimensional gel
electrophoresis; Manadas BJ, Vougas K, Fountoulakis M,
Duarte CB. , Electrophoresis. 2006 May;27(9):1825-31, I.F. 4.10,
Link |
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- Neuroprotection
by BDNF against glutamate-induced apoptotic cell death is mediated
by ERK and PI3-kinase pathways, Almeida, R.D., Manadas. B.J., Melo, C.V., Gomes, J.R., Mendes, C.S.,
Grãos, M., Carvalho. R.F.,
Carvalho, A.P. and Duarte, C.B.,. Cell Death and Differentiation,
2005, 12:1329-1343; IF:7.785,
Link |
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- Intracellular signaling mechanisms in photodynamic therapy; Almeida, R.D., Manadas,
B.J., Carvalho, A.P. and Duarte, C.B.,. Biochim Biophys Acta. 2004
Sep 20; 1704(2):59-86; IF:16.120,
Link |
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