Mass spectrometry is a
powerful analytical technique that is used to identify and quantify
compounds, and to elucidate the structure and chemical properties of
The Unit is specialized in
quantification of proteins from simple and complex samples,
quantification of post-translational modifications,
quantification of drugs and metabolites.
We also aim to identify
biomarkers through proteomics and metabolomics techniques with the
purpose of developing new prognosis and diagnosis methods, in
collaboration with other R&D units at CNC and Biocant and external
partners through our excellence networks.
This unit is equipped with state of the art
-uni- and bi-dimensional separation of drugs,
metabolites, peptides and digested proteins from complex samples by
capillary- to analytical-HPLC;
-mass spectrometry identification and quantification
using distinct sample ionization and scan methods, in an hybrid
instrument that takes advantage of the selectivity provided by the
triple quadrupole and the sensitivity of the ion-trap.
4000 QTRAP mass spectrometer
was acquired with founds from "Programa Nacional de Reequipamento
and the CNC is
member of the Portuguese National Mass Spectrometry Network
Triple TOF5600 - Eksigent nanoLC, A aquisição destes equipamentos foi financiada através do QREN - Programa Operacional Regional do Centro 2007-2013 com o apoio do Mais Centro e da União Europeia no âmbito do projeto "CNC Biotech - investigação em Biotecnologia e capacitação do sector empresarial"
submitted to the Unit will be processed in accordance with
Facility Policy and Users